Agammaglobulinemia

: It is most commonly caused by mutations in the BTK gene , which is essential for B cell development. Common Types

Symptoms usually appear between as maternal antibodies fade. X-Linked Agammaglobulinemia - StatPearls - NCBI Bookshelf agammaglobulinemia

: Patients have a "pan-hypogammaglobulinemia," meaning all major classes of antibodies (IgG, IgA, IgM) are nearly absent. : It is most commonly caused by mutations

: A rarer form that can affect both males and females, caused by mutations in other genes like IGHM or CD79A . Symptoms & Complications : A rarer form that can affect both

Agammaglobulinemia is a rare genetic disorder where the immune system cannot produce enough (immunoglobulins) to fight off germs . People with this condition have very low levels of protective proteins, making them highly susceptible to severe and frequent infections. Core Characteristics

: Also known as Bruton's agammaglobulinemia , this accounts for 85–90% of cases and primarily affects males because the gene is on the X chromosome.