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Beyond leukemia, RARα signaling is being explored as a target for solid tumors.

: Researchers have identified an S100A9–ALDH1A1–RA axis that drives brain metastasis in EGFR-mutant lung cancer. Inhibiting RAR receptors has shown potential in dramatically reducing these relapses. ALPHA.rar

Safety and pharmacokinetics of the non-hormonal male ... - Nature Beyond leukemia, RARα signaling is being explored as

: It functions as a non-hormonal oral male contraceptive that impairs retinoic acid signaling in the testes to decrease sperm count. ALPHA.rar