Amyloid Protein Plaque -

The process begins with the , a protein typically found in the membranes of neurons.

Once plaques establish themselves in the brain's cortex and hippocampus, they cause significant damage: amyloid protein plaque

Understanding Amyloid Protein Plaques: The Biological Hallmarks of Alzheimer's The process begins with the , a protein

: Enzymes called secretases (specifically β-secretase and γ-secretase) cut APP into smaller fragments. The process begins with the

Amyloid protein plaques are hard, insoluble accumulations of proteins that build up in the spaces between nerve cells (neurons) in the brain. Considered a primary hallmark of Alzheimer's Disease (AD) , these plaques disrupt critical cell-to-cell communication and trigger a cascade of neurodegeneration. 1. How Plaques Form