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Using antibodies to bind to extracellular tau species, preventing them from being taken up by healthy neighboring neurons.
Stopping tau proteins from sticking together to form toxic seeds. antitauon
Promoting the removal of pathological tau via microglia or through intracellular degradation pathways like the proteasome. Key Therapeutic Strategies Using antibodies to bind to extracellular tau species,
While many antitauon therapies have reached clinical trials, results have been mixed: antitauon
Current research focuses on both to combat these tauon species: Example Agents / Trials Passive Immunotherapy
Using antisense oligonucleotides (ASOs) or "intrabodies" to reduce tau levels within the cell.