: Upon re-exposure, allergens cross-link IgE on the surface of mast cells, causing degranulation and the release of inflammatory mediators like histamine and leukotrienes. 2. The Atopic March
: Often the first sign in infancy, caused by skin barrier defects (e.g., filaggrin mutations) that allow for epicutaneous allergen sensitization. : Upon re-exposure, allergens cross-link IgE on the
The core of atopy is a Type I hypersensitivity reaction driven by a Type 2 immune response. : Upon re-exposure
: These cells produce cytokines (IL-4, IL-13) that trigger B cells to differentiate into plasma cells producing allergen-specific IgE. caused by skin barrier defects (e.g.
: Systemic immune priming eventually leads to upper and lower airway inflammation. 3. Key Management Strategies