Off (unless playing slow-paced V-Sync games).
Off (unless you have a high-end GPU and want to run higher resolutions). Best Nvidia Control Panel Setting Optimizations...
Off (or cap it 3 FPS below your monitor's refresh rate if using G-Sync). Monitor Technology: G-Sync (if available). Multi-Frame Sampled AA (MFAA): Off. Power Management Mode: Prefer maximum performance. Texture Filtering - Anisotropic Sample Optimization: On. Texture Filtering - Negative LOD Bias: Allow. Off (unless playing slow-paced V-Sync games)