Major depressive disorder (MDD) is a chronic psychiatric condition characterized by persistent sadness, loss of interest (anhedonia), and physical symptoms that significantly impair daily life. By 2030, the World Health Organization projects it will be the leading cause of global disease burden.
: A more chronic form where a depressed mood lasts for at least two years. Theories of Pathogenesis depressive disorder
Diagnosis typically requires a persistently low mood or decreased pleasure in most activities for at least two weeks. Major depressive disorder (MDD) is a chronic psychiatric
: Significant changes in appetite or weight, sleep disturbances (insomnia or hypersomnia), and psychomotor agitation or retardation. loss of interest (anhedonia)
: Feelings of guilt or worthlessness, poor concentration, and recurrent thoughts of death or suicide.