Use the PCSX2 emulator to play the PlayStation 2 version, which can be upscaled to 4K resolution.
Ed, Edd n Eddy: The Mis-Edventures (2005) is no longer available on major digital storefronts like Steam or GOG . Because the publisher, Midway Games, went bankrupt in 2010, the title is often categorized as "abandonware". If you're looking to play it today, here are your options: Ed, Edd n Eddy: The Mis-Edventures PC Download ...
Many fans prefer emulating the console versions because they often run more reliably on modern PCs: Use the PCSX2 emulator to play the PlayStation