Akt_collection_compressed_2022-11-20.zip ... | File:

Multi-Isoform AKT Signaling: A Systems-Level Analysis of Cellular Homeostasis and Oncogenesis

Somatic mutations in AKT, particularly the , alter the PH domain structure, leading to constitutive membrane localization and hyperactivation of downstream effectors like mTOR and ERK1/2. This promotes uncontrolled proliferation and resistance to apoptosis. AKT1 Transcriptomic Landscape in Breast Cancer Cells - MDPI File: AKT_collection_compressed_2022-11-20.zip ...

: The primary regulator of insulin-dependent glucose uptake in muscle and adipose tissue. : Predominantly expressed in the brain, where it

: Predominantly expressed in the brain, where it regulates organ size and neurodevelopment. 3. Pathological Dysregulation 3.1 Cancer AKT acts as a central hub, receiving signals

The PI3K/AKT/mTOR signaling axis is one of the most frequently dysregulated pathways in human disease. AKT acts as a central hub, receiving signals from receptor tyrosine kinases (RTKs) and G-protein-coupled receptors (GPCRs). Upon recruitment to the plasma membrane via its PH domain, AKT is activated by phosphorylation at T308 and S473. 2. Isoform-Specific Functions

: Central to cell survival and general growth; its depletion leads to significant transcriptomic shifts in breast cancer cells.

We found that changes in the cellular levels of AKT1 lead to changes in the levels of a set of differentially expressed genes and, Akt isoforms in the immune system - Frontiers