: In malignant brain tumors like glioblastoma, RAR-independent RXR signaling has been identified as a factor that supports the proliferation and survival of stem-like tumor cells.
The RXR–RAR–DR5 complex is a primary driver of gene expression. This complex functions through: FrSi_TCRSR.part5.rar
: High glucose levels can suppress the transcriptional activity of RAR/RXR, promoting oxidative stress and cardiomyocyte apoptosis . This is linked to the phosphorylation and degradation of the receptors via the JNK pathway. FrSi_TCRSR.part5.rar
