Microsoft Office 2021 for Mac LTSC (Long Term Servicing Channel) version 16.59 is a volume-licensed (VL), non-subscription version of the productivity suite designed for specific commercial and government environments. Unlike standard Microsoft 365 versions, this "perpetual" license is aimed at regulated devices that cannot accept frequent feature updates or systems that lack consistent internet connectivity.

: Features a focus mode, improved immersive reader with line focus, and accessibility improvements.

: Features a redesigned interface and support for duplicating calendar events.

Note: Some applications available on Windows, such as Access and Publisher, are not available for macOS. Microsoft Office 2021 for Mac LTSC v16.59 VL

: Included as the standard desktop application for note-taking.

: Includes new data analysis tools such as XLOOKUP , XMATCH , and Dynamic Arrays .

The LTSC 2021 suite for Mac includes several key desktop applications tailored for the macOS ecosystem: