When searching for ISO files, be extremely careful. Sites offering "Free ISO Downloads" are often hotspots for malware.
Ensure the file ends in .iso . Never run a .exe file that claims to be a game console image. NBA 2K16 [Region Free][ISO]
If you're running this on an original console, it usually requires a "soft-mod" (like Brew on PS3) to boot ISO files directly from a hard drive. A Quick Warning on Safety When searching for ISO files, be extremely careful