In the South Park episode " Turd Burglars " (S23E8), the women of the town fall ill following a chaotic, DIY, Dune -inspired trend of performing fecal transplants on themselves. To save the day, the boys are tasked with stealing the "spice melange" (healthy stool) from Tom Brady. Meanwhile, Kyle faces an existential crisis over the microorganisms inhabiting his own body. This episode can be watched on Apple TV and summarized on Wikipedia .