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Renormalization — [s2e21] The Vegas

Leonard and Raj take a depressed Howard to Las Vegas to help him forget his heartbreak. When Howard refuses to leave his hotel room—spending his time stalking Leslie on Facebook and posting "depressing Twitters"—the guys decide to take drastic measures.

Howard eventually realizes she’s a professional but, instead of being offended, is deeply touched that his friends would do that for him and continues the "experience". Sheldon's "Fortress of Solitude" [S2E21] The Vegas Renormalization

Back in Pasadena, Sheldon plans a glorious weekend of being alone, eating Indian food that the others can't have due to allergies or personal distaste (paneer). Leonard and Raj take a depressed Howard to

Howard's ringtone is "She Blinded Me with Science," which was the theme song for the show's original, unaired pilot. Sheldon's "Fortress of Solitude" Back in Pasadena, Sheldon

By the time Leonard returns, Sheldon claims to have a better understanding of "friends with benefits," a concept he learned from Penny, which hilariously confuses Leonard. Fun Facts & Trivia

Sheldon ends up taking over Penny's bed and annoying her into singing "Soft Kitty" because he feels "homesick".