[s5e22] What A Difference A Day — Makes

: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to.

In , the Season 5, Episode 22 milestone titled " What a Difference a Day Makes " is a landmark 100th episode that originally aired on May 7, 2009. It is widely celebrated for its emotional depth, shifting from a planned grand wedding for Meredith and Derek to a poignant ceremony for Izzie Stevens and Alex Karev. The Unexpected Wedding [S5E22] What a Difference a Day Makes

: As a wedding gift, Derek gives Meredith her first solo surgery—a successful colon surgery overseen by Richard Webber. : To promote the 100th episode, ABC created