Sepsis: Definitions, Pathophysiology And The Ch... [ 2025 ]

: Life-threatening organ dysfunction identified by an acute change in the SOFA score (Sequential Organ Failure Assessment) of ≥2is greater than or equal to 2 points consequent to an infection.

The international consensus (Sepsis-3) has updated the terminology to reflect a deeper biological understanding: Sepsis: Definitions, Pathophysiology and the Ch...

Sepsis pathophysiology is an intertwined cascade of immune, endothelial, and coagulation dysfunctions: Sepsis—Pathophysiology and Therapeutic Concepts - PMC : Life-threatening organ dysfunction identified by an acute

: A subset of sepsis involving profound circulatory, cellular, and metabolic abnormalities. It is clinically identified by the need for vasopressors to maintain a mean arterial pressure of ≥65is greater than or equal to 65 mmHg and a serum lactate level >2is greater than 2 mmol/L despite adequate fluid resuscitation. Sepsis: Definitions, Pathophysiology and the Ch...