Usually a low-quality, 3D-rendered spinning skull or a skeleton with a guitar.

It’s built on a blues shuffle in the key of G. The main riff follows a 1-1-1, 4-1, 5-4 pattern.

The most common "skeleton riff" is the opening of George Thorogood's classic. Standard (E A D G B E).

The meme typically subverts expectations by using a "tough" aesthetic to deliver punchlines that are either intentionally "lazy" or surprisingly mundane.

The riff is a badly looped, high-distortion sample from "Bad to the Bone" .

The "Skeleton with Guitar Riff" meme—often featuring a accompanied by George Thorogood’s iconic opening riff from "Bad to the Bone" —is a cornerstone of internet subculture that blends irony, edge, and nostalgia. Whether you are a creator looking to use the meme or a guitarist wanting to play it, this guide covers everything you need to know. The Anatomy of a Viral Meme

If you want to master the sound behind the meme, you can learn the actual "Skeleton Riff" or its meme inspiration.