Titlimp4 -

While TIMP1, 2, and 3 are expressed widely, TIMP4 is expressed in a more tissue-specific manner. It acts as the major intraplatelet MMP inhibitor, playing a key role in regulating platelet aggregation. Conclusion: Future Therapeutic Potential

TIMP4 is highly expressed in human cardiovascular tissue, particularly within adipose tissue. Titlimp4

In patients with idiopathic pulmonary arterial hypertension, a higher plasma MMP2/TIMP4 ratio is used as a predictor of disease severity and worsened survival. 3. Role in Pregnancy and Tissue Remodeling While TIMP1, 2, and 3 are expressed widely,

The accumulating evidence suggests that TIMP4 is not just a structural protein but a functional modulator of tumor progression and vascular inflammation. Its ability to regulate MMPs makes it a promising target for therapeutic interventions in cancer metastasis and inflammatory vascular disorders. Its ability to regulate MMPs makes it a

Mice lacking the TIMP4 gene showed increased inflammation, indicating its anti-inflammatory role in diseases.

While MMPs are necessary for remodeling, their overactivity can lead to tissue destruction, tumor invasion, or vascular diseases. TIMP4 steps in to ensure this remodeling does not become destructive. Key Areas of Impact in Current Research 1. Prognostic Marker in Cancer (OSCC/HNSCC)

Lower levels of TIMP4 are directly correlated with metastasis and higher clinical staging.